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孤独感作为一类普遍存在的社会心理应激源，已有研究证实，其可通过调控生物老化进程，加剧机体生理功能退行性变，进而升高慢性疾病的发病风险。口腔健康是全身健康的核心组成部分，口腔是人体微生物定植的核心区域，亦是反映全身健康状况的重要“窗口”，其疾病易感性与孤独感及生物老化进程可能存在密切关联。近来，越来越多的研究结果提示孤独感与口腔疾病之间存在显著关联。与此同时，鉴于社会心理因素在口腔健康中的重要作用，未来研究应基于前瞻性队列设计及基础研究，定期监测孤独感与口腔疾病的关联，阐明二者间的双向因果关系。该文对当前的研究线索进行系统梳理，从两者关联的流行病学证据、可能的关联及机制等方面展开综述，以期为孤独感相关口腔健康问题的防控与临床治疗提供理论支撑。
Abstract：Loneliness， a prevalent psychosocial stressor， has been empirically linked to accelerated physiological decline through its modulation of biological aging pathways， thereby increasing susceptibility to chronic diseases. Oral health is an integral part of systemic health. The oral cavity-serving as both a primary site of microbial colonization and a sensitive systemic health indicator-may reflect bidirectional interactions among loneliness， biological aging， and oral disease pathogenesis. Increasing epidemiological evidence supports a robust association between loneliness and oral diseases. Given the well-established influence of psychosocial determinants on oral health， future research should prioritize longitudinal prospective cohort studies and mechanistic investigations to clarify temporal relationships and causal directions. This review provides a systematic synthesis of current evidence， integrating epidemiological findings， proposed biological and behavioral pathways， and knowledge gaps， with the aim of informing preventive strategies， clinical risk assessment， and targeted interventions for loneliness-related oral health deterioration.
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基本信息:
中图分类号:R780.2
引用信息:
[1]胡景波,孙莹,陈新.孤独感与口腔疾病的关联及其机制研究进展[J].安徽医科大学学报().
基金信息:
国家自然科学基金项目(编号：82373591); 安徽医科大学口腔医学院学科建设项目(编号：2023xkfyts07)
2026-08-28
2026-08-28
2026-08-28