内蒙古科技大学包头医学院研究生院;内蒙古科技大学包头医学院第一附属医院检验科;内蒙古科技大学包头医学院基础医学与法医学院;内蒙古科技大学包头医学院护理学院;
目的 探究PROS1基因单核苷酸多态性(SNP)与包头地区汉族人群复发性流产(RSA)发生风险之间的相关性。方法 选取RSA患者及对照人群各158例作为研究对象，测定蛋白S、蛋白C、抗凝血酶-Ⅲ活性；使用聚合酶链式反应-限制性片段长度多态性(PCR-RFLP)技术对PROS1基因rs13062355、rs6441600和rs12634349位点进行基因分型。采用非条件性Logistic回归分析PROS1基因三种SNP与RSA发生风险的相关性。结果 RSA患者的蛋白S、抗凝血酶-Ⅲ活性下降(P<0.05);PROS1 SNP rs13062355在显性模型下与RSA发病风险相关：与携带TT基因型患者比较，携带CT+CC基因型的患者RSA发病风险下降(OR=0.398,95%CI:0.249～0.638)。SNP rs6441600、rs12634349与RSA的发病风险无关联。在PROS1 rs13062355、rs6441600、rs12634349构建的单体型中，单体型C-C-C在两组间差异有统计学意义(P<0.05);三阶交互模型rs13062355-rs6441600-rs12634349与RSA发病风险相关。结论 PROS1 SNP rs13062355可能与包头地区汉族女性RSA患病风险相关；PROS1 rs13062355、rs6441600、rs12634349的单体型C-C-C降低了RSA发病风险；三阶模型rs13062355-rs6441600-rs12634349的交互作用在RSA的发生中具有协同效应。
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基本信息:
DOI：10.19405/j.cnki.issn1000-1492.2025.02.008
中图分类号:R714.21
引用信息:
[1]赵萍萍,吴涤,李得春等.PROS1基因多态性与包头地区汉族人群复发性流产的关联性[J].安徽医科大学学报,2025,60(02):240-246.DOI:10.19405/j.cnki.issn1000-1492.2025.02.008.
基金信息:
内蒙古自治区卫生健康科技计划项目(编号：202201429); 包头医学院青年科技人才发展计划(编号：BYJJ-QNGG 2022044)~~