| 44 | 3 | 18 |
| 下载次数 | 被引频次 | 阅读次数 |
目的 探讨芸香苷 (Ru)对大鼠急性胰腺炎 (AP)胰腺血流量的影响。方法 经胰胆管内注射 3%牛磺胆酸钠溶液 (1ml/kg)制成SD大鼠急性胰腺炎模型。以芸香苷为预防性保护药物 ,观察不同时相急性胰腺炎大鼠胰腺血流量的变化及胰组织病理改变间内在联系。结果 急性胰腺炎时胰头部血流量明显下降。病理检查示胰腺组织明显坏死和中性粒细胞 (PMN)浸润。预先使用芸香苷 ,可明显增加胰头部血流。胰腺出血及坏死明显减轻。结论 芸香苷可通过增加胰腺血流量 ,减轻胰腺出血和坏死 ,保护胰腺组织。
Abstract：Objective To evaluate the effects of rutosi de(Ru) on the pancreatic blood flow (PBF) during acute pancreatitis (AP) in rats. Methods The model of AP in rats was induced by retrograde injection of sodium taurocholate (3%) into the pancreatobiliary duct(1 ml/kg body weight). The pancreatic blood flow was examined after Ru (30,60,12 0 mg/vg,sc) administration. Results Blood flow in pancreatic head signicantly decreased during acute pancreatitis. The pancreatitis injury was described as evident pancreatic acinus necrosis and polymorphonuclear cell (PWN) infiltration.The pretreatment by Ru ameliorated the abovementioned adverse pathophysiological changes seen in control. Conclusion Ru prevents pancreatic bleeding and necrosis. It protects pancreatic tissue by means of raising pancreatic blood flow.
1 ZhouZG ,ChenYD ,SunWetal.Pancreaticmicrocirculatoryim pairmentinexperimentalacutepancreatitisinrats.WorldJGas troenterol,2002;8(5):933～6
2 田 洁,赵维中,王宇翎等.芸香苷对实验性急性胰腺炎的保护作用.安徽医科大学学报,2002;37(1):31～4
3 A hoHJ,Koskensa loSM,Nevalain enTJ.Experimentalpancreatitisintheratsodiumtaurocho lateinducedacutehaemorrhagicpancr eatitis.ScandJGastroenterol,1980;15(4):411～6
4 陈思锋,吴中立体液和组织磷脂酶A2简便快速测定法.第二军医大学学报,1989;10(5):254～6
5 王兴鹏,吴丽颖.重症急性胰腺炎的病因和发病机制.胃肠病学,2002;7(4):224～6
6 SchmidtJ,EbelingD,RyschichEetal.Pancreaticcapillarybloodflowinanimprovedmodelnecrotizingpancreatitisintherat.JSurgRes,2002;106(2):335～41
基本信息:
DOI：10.19405/j.cnki.issn1000-1492.2003.05.007
中图分类号:R285
引用信息:
[1]陈爱华,司力,赵维中.芸香苷对急性胰腺炎大鼠胰腺血流量的影响[J].安徽医科大学学报,2003(05):347-350.DOI:10.19405/j.cnki.issn1000-1492.2003.05.007.
基金信息:
安徽省科技厅自然科学基金 (编号 :0 10 43 90 7);; 安徽省教育厅自然科学基金 (编号 :2 0 0 1kj0 2 2 )资助课题
2003-10-30
2003-10-30