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目的 分析儿童Wilson病（WD）患者的血脂特点及相关危险因素。方法 回顾性收集315例儿童WD患者及248例健康体检儿童的临床资料，对比分析两组血脂水平的差异；根据血脂水平将WD组分为血脂正常组（85例）和血脂异常组（230例），比较两组一般资料与生化指标，采用多因素Logistic回归分析血脂异常的独立危险因素。结果 儿童WD患者血脂异常发生率为73.0%(230/315)，其中高三酰甘油血症77例（33.5%）、高胆固醇血症11例（4.8%）、混合性高脂血症104例（45.2%）、高脂蛋白a血症9例（3.9%）、低高密度脂蛋白胆固醇血症29例（12.6%）。不同血脂异常类型在年龄分布上差异有统计学意义（P<0.05），在性别分布上差异无统计学意义。与血脂正常组相比，血脂异常组的同型半胱氨酸、超氧化物歧化酶（SOD）、血小板计数（PLT）、纤维蛋白原、丙氨酸氨基转移酶、天冬氨酸氨基转移酶、γ-谷氨酰转移酶、尿酸、胱抑素C(Cys-C)、Ⅳ型胶原（C-Ⅳ）、层粘连蛋白水平均升高（均P<0.05）。多因素Logistic回归显示，C-Ⅳ（OR=5.037, 95%CI:2.562～9.900）、PLT(OR=2.297, 95%CI:1.580～3.339)、Cys-C(OR=2.008, 95%CI:1.395～2.890)和SOD(OR=1.996, 95%CI:1.342～2.970)，均为儿童WD血脂异常的独立危险因素。结论 儿童WD患者血脂异常发生率高，以混合性高脂血症和高三酰甘油血症为主，C-Ⅳ、PLT、Cys-C、SOD是儿童WD患者血脂异常的独立危险因素。
Abstract：Objective To analyze the lipid characteristics and related risk factors of children with Wilson disease(WD).Methods The clinical data of 315 children with WD and 248 healthy children who underwent physical ex‑amination were retrospectively collected. The differences in lipid levels between the two groups were compared. The WD group was divided into the normal lipid group(85 cases) and the dyslipidemia group(230 cases) accord‑ing to lipid levels. General data and biochemical indicators were compared between the two groups, and multivari‑ate Logistic regression analysis was used to analyze the independent risk factors for dyslipidemia in children with WD.Results The incidence of dyslipidemia in children with WD was 73. 0%(230/315), comprising 77 cases(33. 5%) of hypertriglyceridemia, 11 cases(4. 8%) of hypercholesterolemia, 104 cases(45. 2%) of combined hy‑perlipidemia, 9 cases(3. 9%) of hyperlipoprotein(a)emia, and 29 cases(12. 6%) of hypoalphalipoproteinemia. There were statistically significant differences in age distribution among different types of dyslipidemia(P<0. 05), whereas no significant differences were observed in gender distribution(P>0. 05). Compared with the normal lipid group, the dyslipidemia group showed significantly higher levels of homocysteine, superoxide dismutase(SOD), platelet count(PLT), fibrinogen, alanine aminotransferase, aspartate aminotransferase, γ-glutamyl transferase, uric acid, cystatin C(Cys-C), type IV collagen(C-IV), and laminin(all P<0. 05). Multivariate Logistic regres‑sion analysis showed that C-IV(OR = 5. 037, 95% CI: 2. 562–9. 900), PLT(OR = 2. 297, 95% CI: 1. 580–3. 339), Cys-C(OR = 2. 008, 95% CI: 1. 395–2. 890), and SOD(OR = 1. 996, 95% CI: 1. 342–2. 970) were all independent risk factors for dyslipidemia in children with WD.Conclusion Children with WD have a high inci‑dence of dyslipidemia, which is dominated by combined hyperlipidemia and hypertriglyceridemia. C-IV, PLT, Cys-C, and SOD are independent risk factors for dyslipidemia in children with WD.
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基本信息:
DOI：10.19405/j.cnki.issn1000-1492.2026.09.021
中图分类号:R742.4
引用信息:
[1]徐芸芸,花代平,葛淑凡,等.315例儿童Wilson病血脂异常特征及危险因素分析[J].安徽医科大学学报,2026(09):1672-1678.DOI:10.19405/j.cnki.issn1000-1492.2026.09.021.
基金信息:
国家自然科学基金项目(编号:U22A20366); 安徽省中医药科技攻关专项项目(编号:202303a07020004); 安徽省卫生健康科研项目(编号:AHWJ2022b036); 安徽省自然科学基金项目(编号:2208085MH266); 安徽省临床医学研究转化专项项目(编号:202304295107020109)
2026-08-07
2026-08-07
2026-08-07