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目的 探讨CIE 1976 L*a*b*(Lab)颜色空间鉴别早期食管癌和非癌性病变的临床应用价值。方法 选取行白光成像内镜（WLI）和窄带成像内镜（NBI）检查并有病理证实的食管病变患者的内镜图像，从病变区域黏膜及周围正常区域黏膜各选取5个感兴趣区域（ROI）进行标记，提取并统计Lab颜色空间参数，计算颜色差异值（ΔE*）。结果 共纳入符合条件的213例患者数据进行分析。在WLI和NBI模式下，早期食管癌组和非癌组病变区域黏膜颜色存在差异（P<0.05）。与WLI模式相比，NBI模式下早期食管癌和非癌性病变的颜色差异增加（P<0.05）。早期食管癌病变区域的亮度分量值（L*值）低于非癌性病变区域，这种颜色差异在NBI模式下更为显著（P<0.05）。在WLI模式下，早期食管癌和非癌性病变区域黏膜的黄蓝轴分量值（b*值）差异无统计学意义；但在NBI模式下，非癌性病变区域黏膜的b*值高于早期食管癌病变区域黏膜（P<0.05）。而在红绿轴上，早期食管癌与非癌性病变区域黏膜在WLI模式下均呈红色，在NBI模式下呈绿色，两者红绿轴分量值（a*值）差异无统计学意义。结论 早期食管癌和非癌性病变在WLI和NBI下均存在颜色差异，在WLI下早期食管癌颜色表现偏暗，在非放大NBI模式下非癌性病变颜色表现偏黄。Lab颜色空间有助于鉴别早期食管癌与非癌性病变。
Abstract：Objective To explore the clinical application value of CIE 1976 L*a*b*(Lab) color space in the dif‑ferential diagnosis of early esophageal cancer and non-cancerous lesions.Methods We selected the endoscopic images of patients with esophageal lesions confirmed by pathology who underwent white light imaging endoscopy(WLI) and narrow band imaging endoscopy(NBI). Five regions of interest(ROI) were selected respectively from the mucosa of the lesion area and the mucosa of the surrounding normal area for labeling. The Lab color space pa‑rameters were extracted and counted, and the color difference values（ΔE*）were calculated.Results A total of 213 eligible patients were included for analysis in the study. In WLI and NBI modes, there were differences in mu‑cosal color between the early esophageal cancer group and the non-cancer group(P<0. 05). Compared with WLI mode, NBI mode could significantly increase the color difference between early esophageal cancer and noncancerous lesions(P<0. 05). The lightness component value(L* value) of the early esophageal cancer lesion area was lower than that of the non-cancerous lesion area, and this color difference was more significant in the NBI mode(P<0. 05). In WLI mode, there was no significant difference in yellow-blue component value(b* value) between the mucosa of early esophageal cancer and non-cancerous lesions. However, in the NBI mode, the b* value of the mucosa in the non-cancerous lesion area was higher than that in the early esophageal cancer lesion area(P<0. 05). On the red-green axis, the mucosa of the early esophageal cancer and non-cancerous lesions was red in WLI mode and green in NBI mode. There was no significant difference in red-green component value(a* value) between the two groups.Conclusion There are color differences between early esophageal cancer and non-cancerous lesions under WLI and NBI. The color of early esophageal cancer is darker under WLI, and the color of non-cancerous le‑sions is yellower under non-magnified NBI mode. Lab color space is helpful to identify early esophageal cancer and non-cancerous lesions.
[1]Gruner M, Denis A, Masliah C, et al. Narrow-band imaging ver‑sus Lugol chromoendoscopy for esophageal squamous cell cancer screening in normal endoscopic practice:randomized controlled trial[J]. Endoscopy, 2021, 53(7):674-82. doi:10. 1055/a-1224-6822.
[2]王鹏宇，游有鹏，杨雪峰.基于颜色量化和密度峰聚类的彩色图像分割[J].计算机工程与应用，2020(2):211-5. doi:10. 3778/j. issn. 1002-8331. 1810-0147.[2]Wang P Y, You Y P, Yang X F. Color image segmentation based on color quantization and density peak clustering[J]. Comput Eng Appl, 2020,56(2):211-5. doi:10. 3778/j. issn. 1002-8331. 1810-0147.
[3]Murakami T, Kamba E, Nomura K, et al. Linked color imaging improves visibility of colorectal serrated lesion by high color con‑trast to surrounding mucosa[J]. Dig Endosc, 2022, 34(7):1422-32. doi:10. 1111/den. 14374.
[4]Gotoda T, Kanzaki H, Okamoto Y, et al. Tolerability and effi‑cacy of the concentration of iodine solution during esophageal chromoendoscopy:a double-blind randomized controlled trial[J]. Gastrointest Endosc, 2020, 91(4):763-70. doi:10. 1016/j. gie. 2019. 10. 022.
[5]Kuehni R G. Color-tolerance data and the tentative CIE 1976 L a b formula[J]. J Opt Soc Am, 1976, 66(5):497-500. doi:10. 1364/josa. 66. 000497.
[6]尚晓宇，黄敏，公绪平，等.印刷样品的可接受色差优化计算[J].光学学报，2025, 45(1):0133001. doi:10. 3788/AOS241455.[6]Shang X Y, Huang M, Gong X P, et al. Optimization and calcu‑lation of acceptable color difference for printed samples[J]. Acta Opt Sin, 2025, 45(1):0133001. doi:10. 3788/AOS241455.
[7]Paravina R D, Ghinea R, Herrera L J, et al. Color difference thresholds in dentistry[J]. J Esthet Restor Dent, 2015, 27(Suppl 1):S1-9. doi:10. 1111/jerd. 12149.
[8]许婷婷，张朋悦，冯慧，等.早期食管癌患者合并斑驳食管危险因素研究[J].安徽医科大学学报，2024, 59(4):698-702. doi:10. 19405/j. cnki. issn1000-1492. 2024. 04. 022.[8]Xu T T, Zhang P Y, Feng H, et al. Risk factors associated with the presence of multiple Lugol-voiding lesions in patients with early esophageal carcinoma[J]. Acta Univ Med Anhui, 2024, 59(4):698-702. doi:10. 19405/j. cnki. issn100 0-1492. 2024.04. 022.
[9]刘云云，王玉欣，朱季军，等. ME-NBI联合卢戈氏液染色在食管癌高危人群筛查中的诊断价值[J].西部医学，2020,32(7):1007-11. doi:10. 3969/j. issn. 1672-3511. 2020. 07. 015.[9]Liu Y Y, Wang Y X, Zhu J J, et al. Diagnostic value of ME-NBI combined with Lugol's solution staining in screening high-risk population of esophageal cancer[J]. Med J West China, 2020,32(7):1007-11. doi:10. 3969/j. issn. 1672-3511. 2020. 07. 015.
[10]Vu A, Farah C S. Narrow band imaging:clinical applications in oral and oropharyngeal cancer[J]. Oral Dis, 2016, 22(5):383-90. doi:10. 1111/odi. 12430.
[11]Gono K. Narrow band imaging:technology basis and research and development history[J]. Clin Endosc, 2015, 48(6):476-80. doi:10. 5946/ce. 2015. 48. 6. 476.
[12]Uraoka T, Igarashi M. Development and clinical usefulness of a unique red dichromatic imaging technology in gastrointestinal en‑doscopy:a narrative review[J]. Therap Adv Gastroenterol,2022, 15:17562848221118302. doi:10. 1177/17562848221118302.
[13]Saito M, Koike T, Ohara Y, et al. Linked-color imaging may help improve the visibility of superficial Barrett's esophageal ad‑enocarcinoma by increasing the color difference[J]. Intern Med,2021, 60(21):3351-8. doi:10. 2169/internalmedicine.6674-20.
[14]Kato M, Ono S, Kawada K, et al. Diagnostic performance of linked color imaging for gastric cancer by Helicobacter pylori infec‑tion status:a subanalysis of the large-scale, multicenter random‑ized controlled trial LCI-FIND[J]. Helicobacter, 2024, 29(2):e13080. doi:10. 1111/hel. 13080.
[15]Liu B, Zhang B, Qi J, et al. Targeting MFGE8 secreted by can‑cer-associated fibroblasts blocks angiogenesis and metastasis in esophageal squamous cell carcinoma[J]. Proc Natl Acad Sci USA, 2023, 120(42):e2307914120. doi:10. 1073/pnas.2307914120.
[16]王德淳，李若冰，李鑫圻，等.嗜酸细胞性食管炎的诊治现状及进展[J].中华内科杂志，2025, 64(3):261-5. doi:10. 3760/cma. j. cn112138-20240930-00629.[16]Wang D C, Li R B, Li X Q, et al. Diagnosis and treatment status and progress of eosinophilic esophagitis[J]. Chin J Intern Med,2025, 64(3):261-5. doi:10. 3760/cma. j. cn112138-20240930-00629.
[17]柴大敏，胡建国，鲍正齐，等.血管生成拟态、VEGF-D和MVD在食管鳞状细胞癌组织中表达的临床意义[J].四川大学学报（医学版），2013, 44(5):832-5. doi:10. 13464/j. scux‑byxb. 2013. 05. 032.[17]Chai D M, Hu J G, Bao Z Q, et al. Clinical significance of ex‑pression of vasculogenic mimicry, VEGF-D and MVD in esopha‑geal squamous cell carcinoma[J]. J Sichuan Univ(Med Sci),2013,44(5):832-5. doi:10. 13464/j. scuxbyxb. 2013. 05. 032.
[18]丁亚利，陈日寿，曾今诚，等.图像增强内窥镜在结直肠病变检测中的应用进展[J].实用医学杂志，2024, 40(21):3006-12. doi:10. 3969/j. issn. 1006-5725. 2024. 21. 008.[18]Ding Y L, Chen R S, Zeng J C, et al. Application progress of im‑age-enhanced endoscopy in detection of colorectal lesions[J]. J Pract Med, 2024, 40(21):3006-12. doi:10. 3969/j. issn. 1006-5725. 2024. 21. 008.
基本信息:
DOI：10.19405/j.cnki.issn1000-1492.2026.04.018
中图分类号:R735.1
引用信息:
[1]张永新,陈涵文,樊人瑜,等.基于Lab颜色空间鉴别早期食管癌与非癌性病变的探索性研究[J].安徽医科大学学报,2026,61(04):729-735.DOI:10.19405/j.cnki.issn1000-1492.2026.04.018.
基金信息:
国家自然科学基金项目（编号：82103040）~~
2026-02-09
2026-02-09
2026-02-09