安徽医科大学第一附属医院肿瘤内科;
目的探讨程序性死亡配体-1(PD-L1)和程序性死亡受体-1(PD-1)在胃癌组织中的表达及其与患者临床病理特征的关系。方法收集151例行胃癌根治术患者的肿瘤组织标本及其对应的74例转移淋巴结标本,以及20例癌旁组织标本,采用免疫组织化学法检测其中PD-L1和PD-1蛋白表达,并分析其与患者各项临床指标关系。结果 PD-L1和PD-1在胃癌细胞及癌间质淋巴细胞表达较癌旁组织明显升高,阳性率分别为60.93%和38.41%;癌旁组织不表达PDL1和PD-1;在转移淋巴结的表达与对应肿瘤组织一致,一致率分别为82.43%和87.84%。胃癌组织PD-L1和PD-1表达不相关。PD-L1表达与p TNM分期、浸润层面、淋巴结转移情况及脉管癌栓相关(P<0.05),PD-1与各临床指标不相关。结论 PD-L1和PD-1在胃癌组织中表达显著升高,并与胃癌患者临床病理特征密切相关;PD-L1可能成为预测胃癌进展和预后的新分子标志物,阻断PD-L1/PD-1信号通路有望成为胃癌免疫治疗的新策略。
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基本信息:
DOI：10.19405/j.cnki.issn1000-1492.2015.06.024
中图分类号:R735.2
引用信息:
[1]吴圣,邵婧怡,王芳等.PD-L1和PD-1在胃癌组织中的表达及其临床意义[J].安徽医科大学学报,2015,50(06):821-825.DOI:10.19405/j.cnki.issn1000-1492.2015.06.024.
基金信息:
国家自然科学基金(编号:81272739);; 安徽省科技攻关项目(编号:12010402122)