2013 08 v.48 988-992
强直性脊柱炎流行病学研究进展
基金项目(Foundation):
国家自然科学基金(编号:30771849、30972530、81273169);;
安徽省自然科学基金(编号:090413133)
邮箱(Email):
DOI:
10.19405/j.cnki.issn1000-1492.2013.08.037
中文作者单位:
安徽医科大学公共卫生学院流行病与卫生统计学系;
摘要(Abstract):
强直性脊柱炎(AS)是一种慢性炎症性自身免疫性疾病,主要侵犯骶髂关节、中轴骨骼,并可累及外周关节、肌腱韧带附着点及其他组织。目前AS的病因及发病机制尚不明确。流行病学研究能够帮助人们认识疾病的发展规律、探索病因、预防疾病。现从患病率与发病率、性别分布、年龄分布、易感因素、流行病学挑战等方面对AS的流行病学研究进展进行综述,为AS的相关研究提供更为全面的信息。
关键词(KeyWords):
强直性脊柱炎;;流行病学;;患病率
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参考文献
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[29]Mielants H,Veys E M,Goemaere S,et al.Gut inflammation in thespondyloarthropathies:clinical,radiologic,biologic and genetic fea-tures in relation to the type of histology.A prospective study[J].JRheumatol,1991,18(10):1542-51.
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[2]Carbone L D,Cooper C,Michet C J,et al.Ankylosing spondylitisin Rochester,Minnesota,1935-1989.Is the epidemiology chan-ging[J].Arthritis Rheum,1992,35(12):1476-82.
[3]Kaipiainen-Seppanen O,Aho K,Heliovaara M.Incidence and prev-alence of ankylosing spondylitis in Finland[J].J Rheumatol,1997,24(3):496-9.
[4]Bakland G,Nossent H C,Gran J T.Incidence and prevalence ofankylosing spondylitis in northern norway[J].Arthritis Rheum,2005,53(6):850-5.
[5]Feldtkeller E,Khan M A,van der Heijde D.Age at disease onsetand delayed diagnosis of spondyloarthropathies[J].Z Rheumatol,1999,58(1):21-30.
[6]段振华,潘发明,梅杨,等.强直性脊柱炎患者445例流行特征分析[J].中国公共卫生,2011,27(3):341-2.
[7]宋慧,胡载颖,吴沪生,等.中国南北方强直性脊柱炎患者临床特点对比分析[J].新医学,2011,42(3):147-53.
[8]冯静,朱平,冯媛,等.强直性脊柱炎622例相关因素分析[J].陕西医学杂志,2012,41(2):180-1.
[9]王凌,张华,马新美,等.枣庄地区脊柱关节病流行病学调查[J].医药论坛杂志,2011,32(15):19-21.
[10]Brown M A,Laval S H,Brophy S,et al.Recurrence risk modellingof the genetic susceptibility to ankylosing spondylitis[J].AnnRheum Dis,2000,59(11):883-6.
[11]Burton P R,Clayton D G,Cardon L R,et al.Association scan of14 500 nonsynonymous SNPs in four diseases identifies autoimmu-nity variants[J].Nat Genet,2007,39(11):1329-37.
[12]Wang X,Huang J,Lin Z,et al.Single-nucleotide polymorphismsand expression of IL23R in Chinese ankylosing spondylitis patients[J].Rheumatol Int,2010,30(7):955-9.
[13]Rueda B,Orozco G,Raya E,et al.The IL23R Arg381Gln non-syn-onymous polymorphism confers susceptibility to ankylosing spondy-litis[J].Ann Rheum Dis,2008,67(10):1451-4.
[14]Danoy P,Pryce K,Hadler J,et al.Association of variants at 1q32and STAT3 with ankylosing spondylitis suggests genetic overlapwith Crohn's disease[J].PLoS Genet,2010,6(12):e1001195.
[15]Evans D M,Spencer C C,Pointon J J,et al.Interaction betweenERAP1 and HLAB27 in ankylosing spondylitis implicates peptidehandling in the mechanism for HLAB27[J].Nat Genet,2011,43(8):761-7.
[16]Reveille J D,Sims A M,Danoy P,et al.Genome-wide associationstudy of ankylosing spondylitis identifies non-MHC susceptibilityloci[J].Nat Genet,2010,42(2):123-7.
[17]Li C,Lin Z,Xie Y,et al.ERAP1 is associated with ankylosingspondylitis in Han Chinese[J].J Rheumatol,2011,38(2):317-21.
[18]Bang S Y,Kim T H,Lee B,et al.Genetic studies of ankylosingspondylitis in Koreans confirm associations with ERAP1 and 2p15reported in white patients[J].J Rheumatol,2011,38(2):322-4.
[19]Maksymowych W P,Inman R D,Gladman D D,et al.Association ofa specific ERAP1/ARTS1 haplotype with disease susceptibility inankylosing spondylitis[J].Arthritis Rheum,2009,60(5):1317-23.
[20]Pan F,Liao F,Xia G,et al.Association of IL-1F7 gene with sus-ceptibility to human leukocyte antigen-B27 positive ankylosingspondylitis in Han Chinese population[J].Clin Chim Acta,2010,411(1-2):124-6.
[21]张立,潘发明,曾臻,等.安徽汉族人群IL-1F10-3基因rs3811058位点单核甘酸多态性与强直性脊柱炎患者遗传易感性研究[J].安徽医科大学学报,2012,47(3):308-10.
[22]Maksymowych W P,Rahman P,Reeve J P,et al.Association of theIL1 gene cluster with susceptibility to ankylosing spondylitis:an a-nalysis of three Canadian populations[J].Arthritis Rheum,2006,54(3):974-85.
[23]Raychaudhuri S,Remmers E F,Lee A T,et al.Common variants atCD40 and other loci confer risk of rheumatoid arthritis[J].NatGenet,2008,40(10):1216-23.
[24]Martínez A,Pacheco-Tena C,Vázquez-Mellado J,et al.Relation-ship between disease activity and infection in patientswith spondy-loarthropathies[J].Ann Rheum Dis,2004,63(10):1338-40.
[25]曾华,陈凤平,冯修高,等.强直性脊柱炎患者呼吸道病原微生物感染分析[J].实用预防医学,2011,17(11):2150-1.
[26]Ebringer A,Rashid T,Tiwawa H,et al.A possible link betweenCrohn's disease and ankylosing spondylitis via Klebsiella infections[J].Clin Rheumatol,2007,26(3):289-97.
[27]Stone M A,Payne U,Schentag C,et al.Comparative immune re-sponses to candidate arthritogenic bacteria do not confirm a domi-nant role for Klebsiella pneumonia in the pathogenesis of familialankylosing spondylitis[J].Rheumatology(Oxford),2004,43(2):148-55.
[28]van der Paardt M,van Denderen J C,van den Brule A J,et al.Prevalence of Chlamydia trachomatis in urine of male patients withankylosing spondylitis is not increased[J].Ann Rheum Dis,2000,59(4):300-2.
[29]Mielants H,Veys E M,Goemaere S,et al.Gut inflammation in thespondyloarthropathies:clinical,radiologic,biologic and genetic fea-tures in relation to the type of histology.A prospective study[J].JRheumatol,1991,18(10):1542-51.
[30]葛锐,潘发明,夏果,等.强直性脊柱炎FcRL基因与环境暴露因素交互作用研究[J].中国卫生统计,2011,28(6):617-22.
基本信息:
DOI：10.19405/j.cnki.issn1000-1492.2013.08.037
中图分类号:R593.23
引用信息:
[1]吴珊珊,段振华,潘发明.强直性脊柱炎流行病学研究进展[J].安徽医科大学学报,2013,48(08):988-992.DOI:10.19405/j.cnki.issn1000-1492.2013.08.037.
基金信息:
国家自然科学基金(编号:30771849、30972530、81273169);; 安徽省自然科学基金(编号:090413133)