右江民族医学院生命科学研究院;右江民族医学院临床医学院;右江民族医学院基础医学院;
环指蛋白183(RNF183)是一种E3泛素连接酶,它可以催化泛素分子与底物蛋白的共价连接。RNF183在肾脏和睾丸等组织中均有表达,它主要被定位在细胞中的内质网、高尔基体、溶酶体。RNF183作为内质网膜的组成部分之一,参与了内质网应激响应通路影响细胞及蛋白质泛素化。近年来,关于RNF183与结直肠癌、子宫内膜癌和膀胱癌等多种疾病关系的研究逐渐增多。该文对RNF183在结直肠癌、炎症性肠病等疾病中的作用以及内质网应激等生物学功能进行了总结,旨在对相关疾病研究提供参考思路。
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基本信息:
DOI:10.19405/j.cnki.issn1000-1492.2025.02.026
中图分类号:R363
引用信息:
[1]杨睿睿,高诗雨,汪建初等.环指蛋白183的生物学功能及其在疾病中的作用[J].安徽医科大学学报,2025,60(02):366-371.DOI:10.19405/j.cnki.issn1000-1492.2025.02.026.
基金信息:
国家自然科学基金(编号:82060441); 广西自然科学基金(编号:2024GXNSFAA010120); 2021年右江民族医学院“新启航”青年骨干项目(编号:DC2200001896); 广西壮族自治区级大学生创新创业训练计划项目(编号:S202410599064); 右江民族医学院2018年度校级科研课题(编号:RZ2100000376)~~