2024 08 v.59 1302-1306
肿瘤微环境中细胞外囊泡释放对肿瘤免疫的影响
基金项目(Foundation):
国家自然科学基金(编号：82322049、82150103、82071864、82270830);;
科学技术部高技术研究发展中心国家重点研发计划(编号：2022YFA1206000);;
湖北省“青年拔尖人才培养计划”(编号：鄂组通[2021]17号)
邮箱(Email):
ketang@hust.edu.cn;mingjiewh@126.com;
DOI:
10.19405/j.cnki.issn1000-1492.2024.08.002
中文作者单位:
华中科技大学同济医学院生物化学与分子生物学系;华中科技大学同济医学院附属协和医院甲状腺乳腺外科;
摘要(Abstract):
肿瘤微环境(TME)是一张编织极为复杂的网络，肿瘤细胞、基质细胞和免疫细胞通过细胞间的直接接触或细胞因子的旁分泌信号互相影响，形成了复杂的细胞间通讯系统。而近年来，基于细胞外囊泡(EV)的细胞间通讯已成为日益重要的通讯方式。EV可通过传递生物活性物质或通过其表面的配体影响所接触的各种细胞，进而使肿瘤免疫微环境发生巨大变化。因此，整合EV与免疫系统的相互作用和联系对于EV在基础研究和临床实践中的应用具有重要意义。该文综述了TME中不同来源的EV在肿瘤免疫调控中的作用，具体分析了EV在肿瘤免疫调控过程中的作用，旨在为临床肿瘤疾病的诊断和治疗提供新思路。
关键词(KeyWords):
细胞外囊泡;;肿瘤免疫;;肿瘤微环境
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参考文献
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[2] Marar C,Starich B,Wirtz D.Extracellular vesicles in immunomodulation and tumor progression[J].Nat Immunol,2021,22(5):560-70.
[3] Vergani E,Daveri E,Vallacchi V,et al.Extracellular vesicles in anti-tumor immunity[J].Semin Cancer Biol,2022,86(Pt 1):64-79.
[4] Naito Y,Yoshioka Y,Yamamoto Y,et al.How cancer cells dictate their microenvironment:present roles of extracellular vesicles[J].Cell Mol Life Sci,2017,74(4):697-713.
[5] Maacha S,Bhat A A,Jimenez L,et al.Extracellular vesicles-mediated intercellular communication:roles in the tumor microenvironment and anti-cancer drug resistance[J].Mol Cancer,2019,18(1):55.
[6] Ye S B,Zhang H,Cai T T,et al.Exosomal miR-24-3p impedes T-cell function by targeting FGF11 and serves as a potential prognostic biomarker for nasopharyngeal carcinoma[J].J Pathol,2016,240(3):329-40.
[7] Wang X,Shen H,Zhangyuan G,et al.14-3-3ζ delivered by hepatocellular carcinoma-derived exosomes impaired anti-tumor function of tumor-infiltrating T lymphocytes[J].Cell Death Dis,2018,9(2):159.
[8] Chen G,Huang A C,Zhang W,et al.Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response[J].Nature,2018,560(7718):382-6.
[9] Muller L,Simms P,Hong C S,et al.Human tumor-derived exosomes (TEX) regulate Treg functions via cell surface signaling rather than uptake mechanisms[J].Oncoimmunology,2017,6(8):e1261243.
[10] Yamada N,Kuranaga Y,Kumazaki M,et al.Colorectal cancer cell-derived extracellular vesicles induce phenotypic alteration of T cells into tumor-growth supporting cells with transforming growth factor-β1-mediated suppression[J].Oncotarget,2016,7(19):27033-43.
[11] Yin Y,Cai X,Chen X,et al.Tumor-secreted miR-214 induces regulatory T cells:a major link between immune evasion and tumor growth[J].Cell Res,2014,24(10):1164-80.
[12] Rosser E C,Mauri C.Regulatory B cells:origin,phenotype,and function[J].Immunity,2015,42(4):607-12.
[13] Li Y,An J,Huang S,et al.Esophageal cancer-derived microvesicles induce regulatory B cells[J].Cell Biochem,Funct,2015,33(5):308-13.
[14] Yang C,Chalasani G,Ng Y H,et al.Exosomes released from Mycoplasma infected tumor cells activate inhibitory B cells[J].PLoS One,2012,7(4):e36138.
[15] Mantovani A,Sica A.Macrophages,innate immunity and cancer:balance,tolerance,and diversity[J].Curr Opin Immunol,2010,22(2):231-7.
[16] Ying X,Wu Q,Wu X,et al.Epithelial ovarian cancer-secreted exosomal miR-222-3p induces polarization of tumor-associated macrophages[J].Oncotarget,2016,7(28):43076-87.
[17] Pritchard A,Tousif S,Wang Y,et al.Lung tumor cell-derived exosomes promote M2 macrophage polarization[J].Cells,2020,9(5):1303.
[18] Fabbri M,Paone A,Calore F,et al.MicroRNAs bind to Toll-like receptors to induce prometastatic inflammatory response[J].Proc Natl Acad Sci U S A,2012,109(31):E2110-6.
[19] Maji S,Chaudhary P,Akopova I,et al.Exosomal annexin II promotes angiogenesis and breast cancer metastasis[J].Mol Cancer Res,2017,15(1):93-105.
[20] Ning Y,Shen K,Wu Q,et al.Tumor exosomes block dendritic cells maturation to decrease the T cell immune response[J].Immunol Lett,2018,199:36-43.
[21] Chen W,Jiang J,Xia W,et al.Tumor-related exosomes contribute to tumor-promoting microenvironment:an immunological perspective[J].J Immunol Res,2017,2017:1073947.
[22] Terrén I,Orrantia A,Vitallé J,et al.NK cell metabolism and tumor microenvironment[J].Front Immunol,2019,10:2278.
[23] Ashiru O,Boutet P,Fernández-Messina L,et al.Natural killer cell cytotoxicity is suppressed by exposure to the human NKG2D ligand MICA*008 that is shed by tumor cells in exosomes[J].Cancer Res,2010,70(2):481-9.
[24] Nakano T,Chen I H,Wang C C,et al.Circulating exosomal miR-92b:its role for cancer immunoediting and clinical value for prediction of posttransplant hepatocellular carcinoma recurrence[J].Am J Transplant,2019,19(12):3250-62.
[25] Liu H Y,Kumar R,Zhong C,et al.Rapid capture of cancer extracellular vesicles by lipid patch microarrays[J].Adv Mater,2021,33(35):e2008493.
[26] Blanchard N,Lankar D,Faure F,et al.TCR activation of human T cells induces the production of exosomes bearing the TCR/CD3/zeta complex[J].J Immunol,2002,168(7):3235-41.
[27] Hansen A S,Jensen L S,Gammelgaard K R,et al.T-cell derived extracellular vesicles prime macrophages for improved STING based cancer immunotherapy[J].J Extracell Vesicles,2023,12(8):e12350.
[28] Wahlgren J,Karlson T D L,Glader P,et al.Activated human T cells secrete exosomes that participate in IL-2 mediated immune response signaling[J].PLoS One,2012,7(11):e49723.
[29] Cai Z,Yang F,Yu L,et al.Activated T cell exosomes promote tumor invasion via Fas signaling pathway[J].J Immunol,2012,188(12):5954-61.
[30] Wang X,Shen H,He Q,et al.Exosomes derived from exhausted CD8+ T cells impaired the anticancer function of normal CD8+ T cells[J].J Med Genet,2019,56(1):29-31.
[31] Greisen S R,Yan Y,Hansen A S,et al.Extracellular vesicles transfer the receptor programmed death-1 in rheumatoid arthritis[J].Front Immunol,2017,8:851.
[32] Théry C,Boussac M,Véron P,et al.Proteomic analysis of dendritic cell-derived exosomes:a secreted subcellular compartment distinct from apoptotic vesicles[J].J Immunol,2001,166(12):7309-18.
[33] Pitt J M,André F,Amigorena S,et al.Dendritic cell-derived exosomes for cancer therapy[J].J Clin Invest,2016,126(4):1224-32.
[34] Viaud S,Terme M,Flament C,et al.Dendritic cell-derived exosomes promote natural killer cell activation and proliferation:a role for NKG2D ligands and IL-15Ralpha[J].PLoS One,2009,4(3):e4942.
[35] Jong A Y,Wu C H,Li J,et al.Large-scale isolation and cytotoxicity of extracellular vesicles derived from activated human natural killer cells[J].J Extracell Vesicles,2017,6(1):1294368.
[36] Zhu L,Kalimuthu S,Gangadaran P,et al.Exosomes derived from natural killer cells exert therapeutic effect in melanoma[J].Theranostics,2017,7(10):2732-45.
[37] Neviani P,Wise P M,Murtadha M,et al.Natural killer-derived exosomal miR-186 inhibits neuroblastoma growth and immune escape mechanisms[J].Cancer Res,2019,79(6):1151-64.
[38] Wang L,Wang Y,Quan J.Exosomal miR-223 derived from natural killer cells inhibits hepatic stellate cell activation by suppressing autophagy[J].Mol Med,2020,26(1):81.
[39] Lan J,Sun L,Xu F,et al.M2 macrophage-derived exosomes promote cell migration and invasion in colon cancer[J].Cancer Res,2019,79(1):146-58.
[40] Choo Y W,Kang M,Kim H Y,et al.M1 macrophage-derived nanovesicles potentiate the anticancer efficacy of immune checkpoint inhibitors[J].ACS Nano,2018,12(9):8977-93.
[41] Rui R,Zhou L,He S.Cancer immunotherapies:advances and bottlenecks[J].Front Immunol,2023,14:1212476.
[42] Zhang Y,Zhang Z.The history and advances in cancer immunotherapy:understanding the characteristics of tumor-infiltrating immune cells and their therapeutic implications[J].Cell Mol Immunol,2020,17(8):807-21.
[43] Riley R S,June C H,Langer R,et al.Delivery technologies for cancer immunotherapy[J].Nat Rev Drug Discov,2019,18(3):175-96.
[44] Xu P,Tang K,Ma J,et al.Chemotherapeutic tumor microparticles elicit a neutrophil response targeting malignant pleural effusions[J].Cancer Immunol Res,2020,8(9):1193-205.
[45] Gao Y,Zhang H,Zhou N,et al.Methotrexate-loaded tumour-cell-derived microvesicles can relieve biliary obstruction in patients with extrahepatic cholangiocarcinoma[J].Nat Biomed Eng,2020,4(7):743-53.
[46] Wei Z,Zhang X,Yong T,et al.Boosting anti-PD-1 therapy with metformin-loaded macrophage-derived microparticles[J].Nat Commun,2021,12(1):440.
基本信息:
DOI：10.19405/j.cnki.issn1000-1492.2024.08.002
中图分类号:R730.3
引用信息:
[1]黎劼潇,陆枢桠,张佳宁等.肿瘤微环境中细胞外囊泡释放对肿瘤免疫的影响[J].安徽医科大学学报,2024,59(08):1302-1306.DOI:10.19405/j.cnki.issn1000-1492.2024.08.002.
基金信息:
国家自然科学基金(编号：82322049、82150103、82071864、82270830);; 科学技术部高技术研究发展中心国家重点研发计划(编号：2022YFA1206000);; 湖北省“青年拔尖人才培养计划”(编号：鄂组通[2021]17号)
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