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巨胞饮是一种细胞获取胞外营养的重要途径,在肿瘤细胞中,基因突变以及来自肿瘤微环境中的信号,增强了细胞的巨胞饮活动,提高其代谢水平并最终促进肿瘤进展。但是在目前的巨胞饮研究中,一方面从分子生物学层面解释巨胞饮的调控和发生过程还有待进一步探索,另一方面在肿瘤微环境中,不同细胞的巨胞饮活动发挥何种功能也亟需认识。该文主要综述肿瘤微环境中诱导巨胞饮发生的因素,不同细胞内参与巨胞饮活动的重要分子和信号通路,以及在此之上开发的相关靶向药物和转化研究,为读者研究巨胞饮在肿瘤微环境中的作用提供参考。
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基本信息:
DOI:10.19405/j.cnki.issn1000-1492.2024.08.004
中图分类号:R730.2
引用信息:
[1]傅饶,孙倍成.巨胞饮在肿瘤微环境中的研究进展[J].安徽医科大学学报,2024,59(08):1310-1314.DOI:10.19405/j.cnki.issn1000-1492.2024.08.004.
基金信息:
国家自然科学基金(编号:81930086)