安徽医科大学学报

目的　研究黄蜀葵花总黄酮 (TFA)的抗炎、解热作用。方法　采用二甲苯致小鼠耳片肿胀的急性炎症模型和皮下埋植棉球致肉芽组织形成的慢性非特异性炎症模型观察TFA的抗炎作用 ;采用sc松节油或iv大肠杆菌液两种诱发家兔发热的模型观察TFA的解热作用。结果　TFA(2 0 0、1 0 0、50mg/kg)均能有效减轻小鼠右耳肿胀程度 ,TFA50mg/kg可明显抑制大鼠新生肉芽组织形成 ;由sc松节油或iv大肠杆菌液诱发的家兔体温升高 ,TFA可产生不同程度地降低作用。结论　TFA具有良好的抗炎、解热作用

Objective To observe the anti inflammatory and antipyretic effects of TFA. Methods An acute inflammatory model, ear edema induced by dimethylbenzene in mice and a chronical inflammatory model, the generation of granulation tissue induced by sc cotton in rat were adopted to observe the anti inflammatory effect of TFA. In addition, pyretic model evoked by sc turpentine oil or iv escherichia coli liq in rabbit was used to observe the antipyretic effect of TFA. Results TFA(200、100、50 mg/kg) significantly inhibited the ear edema, TFA 50 mg/kg reduced the generation of granulation tissue. TFA caused a decrease of high temperature in rabbit induced by sc turpentine oil or iv escherichia coli liq. Conclusion TFA has satisfactory anti inflammatory and antipyretic effects.