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目的观察白芍总苷(TGP)对大鼠系膜增生性肾小球肾炎(MsPGN)的保护作用,为TGP治疗MsPGN提供实验依据。方法采用胃肠道综合免疫方法建立大鼠MsPGN模型,以不同剂量的TGP干预,以雷公藤多苷为对照,观察TGP对大鼠蛋白尿、血生化指标以及肾组织形态学改变的影响。结果模型组大鼠尿蛋白增加,血肌酐和尿素氮升高,血浆总蛋白和白蛋白下降,模型组的肾小球系膜细胞中至重度增生,系膜基质聚积。灌胃给予TGP干预4周后,给药组的系膜细胞增生、基质聚积减少,大鼠的蛋白尿减轻,血肌酐和尿素氮下降。结论TGP可保护MsPGN大鼠的肾功能,部分逆转受损的肾小球病理改变。
Abstract：Objective To observe the effects of total glucosides of paeony(TGP) on the renal injury in mesangial proliferative glomerulonephritis (MsPGN) rats, and provide experiment evidence for the treatment of MsPGN with TGP. Methods The MsPGN model was induced by gastrointestinal comprehensive immunization. Different doses of TGP were given in treatment group. Tripterygium wilfordii(TW) was given in control group. Urinary protein, blood biochemical parameters and the pathology changes of renal were observed. Results Compared with normal group, the urinary protein, blood createnine(Cre) and urea nitrogen(Bun) increased in model group. The mesangial cells(MC) were found with moderate to severe proliferation and extracellular matrix(ECM)accumulated in glomeruli. After treatment with TGP for four weeks, the damage of the renal structure alleviated markedly in treatment group, and its urinary protein, Cre and Bun significantly decreased. Conclusion TGP improves the renal function and partly reverts the glomerular histopathologyical changes in rats with MsPGN.
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基本信息:
DOI：10.19405/j.cnki.issn1000-1492.2006.02.010
中图分类号:R285.5
引用信息:
[1]周登余,徐星铭,戴宏,等.白芍总苷对大鼠系膜增生性肾小球肾炎的保护作用[J].安徽医科大学学报,2006(02):146-149.DOI:10.19405/j.cnki.issn1000-1492.2006.02.010.
基金信息:
安徽省教育厅自然科学基金资助项目(编号:522115)
2006-04-23
2006-04-23