安徽医科大学学报

目的　研究丹皮酚在体外的细胞毒作用和体内抗肿瘤作用。方法　噻唑兰 (MTT)体外试验法和灌胃给药体内抗肿瘤试验。结果　丹皮酚对体外培养的人红白血病细胞K52 6、人乳腺癌基因细胞T6-17和肝癌细胞BEL 74 0 4的半数抑制浓度 (IC50 )依次为 2 5 38mg/L、10 81mg/L和 93 39mg/L。体内灌胃给予丹皮酚 5 0mg/kg·d-1、2 0 0mg/kg·d-1和 80 0mg/kg·d-1ig× 14d对小鼠肿瘤HepA的抑制率分别为 39 2 6 %～ 4 2 5 5 %、4 9 6 9%～ 5 5 32 %和 6 4 4 2～72 6 4 % ,P <0 0 1,差异有显著性。结论　丹皮酚在体外有细胞毒作用 ,灌胃给药有抗肿瘤作用

Objective To investigate the anti tumor effect of paeonol in vitro and in vivo Methods MTT assay and anti tumor test in vivo were used Results IC 50 of paeonol on K 562 cells,T 6-17 cells and BEL 7404 cells were 25 83 ,10 81 and 93 39 mg/L, respectively Under the dose of 50, 200, 800 mg/kg/d for 14 d, the inhibitory rates of paeonol on HepA in mice were 39 26%～42 55%,49 69%～55 32% and 64 42%～72 64% respectively Conclusion Paeonol possesses anti tumor activities in vitro and in vivo