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抑郁症是一种危害个体身心健康并造成家庭社会严重负担的精神神经系统疾病,其发病机制尚不十分明确。近年来的研究发现,抑郁症患者体内线粒体结构和功能异常,包括线粒体能量代谢障碍和线粒体质量控制体系失调等,目前针对调节线粒体功能的抗抑郁治疗手段也不断更新。现从线粒体能量代谢过程、线粒体质量控制体系和针对前两者的抗抑郁治疗手段三方面,综述线粒体与抑郁症的内在关联,为完善抑郁症发病机制和发掘抗抑郁治疗的新靶点提供新视角。
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基本信息:
DOI:10.19405/j.cnki.issn1000-1492.2023.07.029
中图分类号:R749.4
引用信息:
[1]蒋梦若,王立源,盛慧.抑郁症线粒体相关机制的研究进展[J].安徽医科大学学报,2023,58(07):1233-1238.DOI:10.19405/j.cnki.issn1000-1492.2023.07.029.
基金信息:
国家自然科学基金(编号:81671176)
2023-06-27
2023-06-27
2023-06-27